Novel oxofuryl ester derivatives of penicillin and cephalosporin

Details Novel oxofuryl ester derivatives of penicillin and cephalosporin Novel oxofuryl ester derivatives of penicillin and cephalosporin

1975-02-18

1976-04-20

Schwartz, Gerald A.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260243C, 424246, 424271, C07D49968

Patent

active

039519546

ABSTRACT:
The oxofuryl ester derivatives of 6-(.alpha.-amino-phenylacetamido)penicillanic acid, 7-(.alpha.-aminophenylacetamido)-cephalosporanic acid, or 7-(.alpha. -aminophenylacetamide)desacetoxycephalosporanic acid represented by the general formula ##SPC1##
Wherein A represents ##SPC2##
Wherein R.sup.1 and R.sup.2, which may be the same or different, each represents a hydrogen atom or a lower alkyl group, said R.sup.1 and R.sup.2 may form together a 1,3-butadienylene group, R.sup.3 represents a hydrogen atom or an acetoxy group, and
Means a single bond or a double bond, and acid addition salts of them. When those compounds are orally administered, they are readily absorbed by the intestines and show antibacterial activity by splitting their ester bonds. The rate of absorption of the compounds by the intestines are higher and the toxic property of them is less than those of known compounds similar to the above compounds.

REFERENCES:
patent: 2985648 (1961-05-01), Doyle et al.
patent: 3641001 (1972-02-01), Love et al.
patent: 3647783 (1972-03-01), Pirie
patent: 3697507 (1972-10-01), Frederiksen et al.
patent: 3860579 (1975-01-01), Ferres et al.

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