Novel Organic platinum complex and process for the preparation t

Details Novel Organic platinum complex and process for the preparation t Novel Organic platinum complex and process for the preparation t

1988-03-04

1989-12-12

Doll, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

556137, 548403, C07F 728, A61K 3128

Patent

active

048868949

ABSTRACT:
Novel organic platinum complex of the formula: ##STR1## wherein R.sup.1 is hydrogen atom or a lower alkyl group; R.sup.2 is hydrogen atom, a substituted or unsubstituted lower alkyl group, a lower alkenyl group, a lower alkynyl agroup, a lower alkoxy group, a lower alkanoyl group, amino group, a substituted or unsubstituted nitrogen-containing hetero-monocyclic group, or an oxygen-containing hetero-monocyclic group, Alk is a lower alkylene group, X is carbonyl or sulfonyl group, n is 1 or 2, which has excellent anti-tumor activity against various tumors and is useful as an anti-tumor agent, and a process for the preparation thereof, and a pharmaceutical composition containing said compound.

REFERENCES:
patent: 4115418 (1978-09-01), Gale et al.
patent: 4551502 (1985-11-01), Howell et al.
patent: 4594238 (1986-06-01), Berch
patent: 4614811 (1986-09-01), Gandolfi
patent: 4665210 (1987-05-01), Ditha et al.
Patent Abstracts of Japan, vo. II: No. 101.

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