Novel nucleic acid-containing glycoprotein

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.

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C07K 1514

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active

046634380

ABSTRACT:
Disclosed herein is a nucleic acid-containing glycoprotein having molecular weight of 5,000 to 300,000 as determined by ultracentrifugal method; the weight ratio of protein moiety thereof determined by Lowry-Folin's method to saccharide moiety thereof determined by phenol-sulfuric acid method of in the range of 50/50 to 80/20; N-terminal amino acid thereof consisting essentially of tyrosine, leucine or alanine; leucine-phenylalanine-valine as amino acid sequence at C-terminal thereof; the elementary composition consisting essentially of 35.2 to 49.3% of C, 4.8 to 8.0% of H, 4.3 to 12.3% of N, trace to 2.5% of S, trace to 1.2% of P and the balance of O; the isoelectric point of in the range of pH 2.5 to 5.0; and nucleic acid as a component.

REFERENCES:
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patent: 4202885 (1980-05-01), Asano et al.
patent: 4202969 (1980-05-01), Ueno et al.
patent: 4228275 (1980-10-01), Asano et al.
patent: 4243662 (1981-01-01), Asano et al.
patent: 4271151 (1981-06-01), Hotta et al.
patent: 4289688 (1981-09-01), Hotta et al.

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