Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1988-03-21
1991-12-31
Nucker, Christine
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
435 34, 4351723, 4352523, 4352521, 935 55, 935 72, A61K 39112
Patent
active
050770446
ABSTRACT:
Live vaccines are provided and methods for preparing the live vaccines for protection of a host from a pathogenic microorganism. The vaccines are prepared by introducing at least one modification in a gene involved in at least one, normally at least two, biosynthetic pathways involving the production of products which are unlikely to be found in the disease susceptible host. The modification results in a gene change which cannot be repaired by a single step, e.g. polynucleotide deletions and inversions. Where the aro gene suffers such a change, the resultant auxotrophic mutants require aromatic amino acids, p-aminobenzoic acid and 2,3-dihydroxybenzoic acid or a highly concentrated source of absorbable iron. The auxotrophic mutations have substantially reduced or nonexistent virulence while retaining the desired immunogenicity to initiate the immunogenic response. Various techniques can be employed for providing the desired change.
REFERENCES:
patent: 4550081 (1985-10-01), Stocker
patent: 4735801 (1988-04-01), Stocker
patent: 4837151 (1989-06-01), Stocker
Nucker Christine
Rowland Bertram I.
Stucker Jeffrey
The Board of Trustees of the Leland Stanford Jr. University
LandOfFree
Novel non-reverting shigella live vaccines does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel non-reverting shigella live vaccines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel non-reverting shigella live vaccines will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1508632