Novel nitrosourea derivatives

Details Novel nitrosourea derivatives Novel nitrosourea derivatives

1979-04-16

1981-02-17

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 22, 536 18, 536 53, 536 17R, A61K 3170, C07H 1708

Patent

active

042515157

ABSTRACT:
Novel nitrosourea derivatives are provided which possess a high level of inhibitory activity against leukemia and tumors and other are therefore useful for pharmaceutical purposes. The compounds have the structure: ##STR1## wherein one of X and Y represents a hydroxyl and another of them represents a group --NHCONNOCH.sub.2 CH.sub.2 Cl; R represents a hydrogen, alkyl or aryl; and .about. represents a single bond which may be in the .alpha.- or .beta.-stereochemical configuration and are prepared by nitrosating a corresponding urea compound with a nitrosating agent in a manner known per se.

REFERENCES:
patent: 4057684 (1977-11-01), Kimura et al.
patent: 4086415 (1978-04-01), Suami et al.

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