Novel nitrosourea compounds and process for preparing the same

Details Novel nitrosourea compounds and process for preparing the same Novel nitrosourea compounds and process for preparing the same

1979-05-14

1980-12-23

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 22, 536 53, 536 18, A61K 3170, C07H 1312, A61K 3173

Patent

active

042410525

ABSTRACT:
A nitrosourea compound of the formula: ##STR1## wherein R.sup.1 is an alicyclic group having 3 to 6 carbon atoms, phenyl, phenyl substituted with one to substituents selected from halogen, lower alkyl, lower alkoxy, hydroxy and nitro, or a heteromonocyclic group selected from oxiranyl, tetrahydrofuryl, 1,3-dioxolanyl, 1,4-dioxanyl, morpholino, tetrahydro-S,S-dioxo-thienyl, furyl, thienyl and pyridyl; R.sup.2 is aldopentofuranosyl, aldo-pentopyranosyl, aldo-hexopyranosyl or O-aldo-hexopyranosyl-(1.fwdarw.4)-aldo-hexopyranosyl; and A is a single bond or straight or branched alkylene having one to 3 carbon atoms, is prepared by nitrosation of a compound of the formula: ##STR2## wherein R.sup.1, R.sup.2 and A are the same as above. Said nitrosourea compound is useful as an anti-tumor or anti-leukemic agent however, effectiveness in human beings has not yet been demonstrated.

REFERENCES:
patent: 3577406 (1971-05-01), Hessler
patent: 4086415 (1978-04-01), Suami et al.
patent: 4156777 (1979-05-01), Kimura
patent: 4157439 (1979-06-01), Suami
Noller "Chemistry of Organic Compounds," W. B. Saunders Co., Philadelphia, Pa., 1965, p. 598.

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