Novel nitrosourea compounds and process for preparing the same

Details Novel nitrosourea compounds and process for preparing the same Novel nitrosourea compounds and process for preparing the same

1978-07-10

1980-01-08

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

536 22, 536 53, 536 4, A61K 3170, C07H 1502

Patent

active

041827570

ABSTRACT:
A nitrosourea compound of the formula: ##STR1## wherein R.sup.1 is alkyl of one to six carbon atoms, hydroxyalkyl of one to six carbon atoms, alkenyl of three to five carbon atoms or alkynyl of three to five carbon atoms, R.sup.2 is aldopentofuranosyl, aldo-pentopyranosyl, aldo-hexopyranosyl, O-aldo-hexopyranosyl-(1.fwdarw.4)-aldo-hexopyranosyl or a group of the formula: --CH.sub.2 (CHOH).sub.n CH.sub.2 OH, and wherein n is zero or an integer of one to four. A method of preparation is disclosed whereby said nitrosourea compound is prepared by the nitrosation of a compound of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are the same as above. Said nitrosourea compound is useful as an anti-tumor or anti-leukemic agent.

REFERENCES:
patent: 3577406 (1971-05-01), Hessler
patent: 3767640 (1973-10-01), Suami et al.
patent: 3940383 (1976-02-01), Fujiwara et al.
patent: 4057684 (1977-11-01), Kimura et al.
patent: 4086415 (1978-04-01), Suami et al.

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