Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-03-27
1986-10-28
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514255, 544359, 544360, 540492, A61K 3155, A61K 31495, C07D40104
Patent
active
046199276
ABSTRACT:
Novel nitropyrazinyl- and nitropyridinyl- substituted piperazin-3-one and hexahydro-1H-1,4-diazepin-5-one compounds are disclosed to have activity in increasing the sensitivity of hypoxic tumor cells to radiation. Also disclosed are methods of preparing such compounds and pharmaceutical compositions including such compounds.
REFERENCES:
patent: 4414215 (1983-11-01), Hartman
patent: 4416882 (1983-11-01), Hartman
patent: 4418062 (1983-11-01), Hartman
patent: 4435400 (1984-03-01), Hartman
patent: 4438266 (1984-03-01), Hartman
Engelhardt Edward L.
Saari Walfred S.
Arther Thomas E.
Bond Robert T.
Merck & Co. , Inc.
Pfeiffer Hesna J.
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