Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1960-03-10
1977-09-13
Randolph, John D.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424267, C07D22126
Patent
active
040481786
ABSTRACT:
N-Allyl-benzmorphan compounds having structures distinguished by having either a 4,5 or 6 carbon containing allyl group at the 2- or N-position or various ether derivatives of the 2'-hydroxy group. The compounds are prepared by alkylation of appropriate N-nor bases and have analgetic antagonist activity particularly pronounced in countering the effects of overdosing. Certain N-acyl-2'-hydroxy-5,9-dimethyl-6,7-benzmorphan intermediates are also disclosed.
REFERENCES:
patent: 3345373 (1967-10-01), Gordon et al.
patent: 3723440 (1973-03-01), Freter et al.
Gordon Maxwell
Lafferty John J.
Edgerton William H.
Foggio Richard D.
Lourie Alan D.
Randolph John D.
Smith Kline & French Laboratories
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