Novel N-acetyl-.beta.-D-glucosamine derivatives and a process fo

Details Novel N-acetyl-.beta.-D-glucosamine derivatives and a process fo Novel N-acetyl-.beta.-D-glucosamine derivatives and a process fo

1989-02-02

1991-07-09

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 4, 435 7, 435 16, 435 18, 514893, 536 173, 536 177, 536 185, 544102, C07H 1700

Patent

active

050307215

ABSTRACT:
Novel N-acetyl-.beta.-D-glucosamine derivatives represented by the following formula: ##STR1## wherein R represents a hydrogen atom or an acyl group; and X represents a nitrogen atom or an oxide of nitrogen, are disclosed. The glucosamine derivatives are useful for determination of N-acetyl-.beta.-D-glucosaminidase in body fluids as an index of renal diseases.

REFERENCES:
patent: 4737466 (1988-04-01), Klein et al.
patent: 4954630 (1990-09-01), Klein et al.
Dance et al., "B-Galactosidase, B-Glucosidase and N-Acetyl-B-Glucosaminidase in Human kidney," Clinica Chimica Acta, 24:189-197 (1969).
Li et al., "A-Mannosidase, B-N-Acetylhexosaminidase, and B-Calactosidase from Jack Bean Meal," Methods Enzymol., 28:702-713, (1972).
Noto et al., "Simple, Rapid Spectrophotometry of Urine N-Acetyl-B-D-Glucosaminidase, with Use of a New Chromogenic Substrate,"Clin. Chem., 29:1713-1716, (1983).

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