Novel mutation of the c-K-ras oncogene activated in a human lung

Details Novel mutation of the c-K-ras oncogene activated in a human lung Novel mutation of the c-K-ras oncogene activated in a human lung

1984-01-19

1988-02-16

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Vector, per se

435 68, 435 70, 4351723, 435235, 536 27, 935 9, 935 66, C12N 100, C12N 1500, C12P 2100, C07H 1512

Patent

active

047255501

ABSTRACT:
A c-Kirsten ras oncogene has been isolated from a human lung tumor cell line. This c-Kirsten ras has a mutation in codon 61 of the second coding exon and is capable of transforming NIH/3T3 mouse fibroblast cells to tumorigenic cells.

REFERENCES:
patent: 4535058 (1985-08-01), Weinberg et al.
Taparowsky et al, 1983, "Structure and Activation of the Human N-ras Gene", Cell, v34, 581-586.
Rein et al, 1985, "Mutational Activation of Proto-Oncogenes", Molecular Basis of Cancer, Part A . . . , pp. 357-368, Alan R. Liss, Inc.
Notario et al, 1984, "A Common Mechanism for Malignant Activation of ras Oncogenes in Human Neoplasia . . . ", Cancer Cells, v2, 425-432.
Nakano et al, 1984, "Structure and Mechanisms of Activation of the ci-ki-ras Oncogene . . . ", Cancer Cells, v2, 447-454.
Kraus et al, 1984, "A Position 12-Activated H-ras Oncogene in all HS578T Mammary Carcinosarcoma Cells but not Normal Mammary Cells . . . ", PNAS, v81, pp. 5384-5388.
Sekiya et al, 1984, "Molecular Cloning and the Total Nucleotide Sequence of the Human c-Ha-ras-1 gene . . . ", Proc. Natl. Acad. Sci., v81, 4771-4777.
Nakano et al, 1984, "Isolation of Transforming Sequences of Two Human Lung Carcinomas: Structure and Functional Analysis . . . ", Proc. Natl. Acad. Sci., v 81, pp. 71-75.
Shimizu et al, 1983, "Three Human Transforming Genes Are Related to the Viral ras Oncogenes", Proc. Natl. Acad. Sci., v80, pp. 2112-2116.
Der et al, 1982, "Transforming Genes of Human Bladder and Lung Carcinoma Cell Lines are Homologous . . . ", Proc. Natl. Acad. Sci., v79, 3637-3640.

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