Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1985-12-10
1989-03-28
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
4352521, 424 93, H61K 3902, C12N 120
Patent
active
048162531
ABSTRACT:
A novel mutant strain of Listeria monocytogenes, termed by me "Listeria monocytogenes akka", has been discovered which functions as a killed strain not only as an antigen resulting in the production of relatively large titers of IgM antibodies in host animals but also as an immunopotentiating agent when conjugated to a sensitising antigen, for example, living tumor cells and herpes simplex virus. The high molecular weight IgM antibodies are readily separated from serum and recovered without loss of appreciable activity. The IgM antibodies can be divided into five subunits of IgG antibodies, of lesser molecular weight, having the same specificity as the IgM immunoglobulins. When the sensitizing antigens conjugated with the Listeria monocytogenes strain of this invention are tumor cells, the conjugate acts as an immunotherapeutic agent effective in cancer immunotherapy.
REFERENCES:
patent: 3766162 (1973-10-01), Spector et al.
patent: 3809782 (1974-05-01), Spector
Gatewood Herbert L.
Hazel Blondel
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