Novel monoclonal hybridoma and corresponding antibody

Details Novel monoclonal hybridoma and corresponding antibody Novel monoclonal hybridoma and corresponding antibody

1983-12-05

1988-03-15

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Lymphokine

43524027, 4351722, 530395, 935103, 424 88, A61K 39395, A61K 3900, C12N 500, C07K 1514

Patent

active

047312386

ABSTRACT:
The invention concerns a novel lymphocyte hybridoma and an antibody which may be generated from the hybridoma. The hybridoma and antibody have the internal designation LICR-LON-Fib 75. The origin, method of preparation and uses are discussed. The antibody has particular application in the diagnosis and treatment of cancer of the breast. A particular therapeutic treatment comprises harvesting a sample of bone marrow from a patient, subjecting the patient to treatment adapted to kill cancerous material including that within the bone marrow (possibly including the normal differentiated haemopoietic cells of the marrow), subjecting some or all of the sample to cytotoxic treatment with the antibody (or a toxin conjugate thereof) adapted to kill cancerous cell lines while leaving viable colony-forming units of bone marrow, and reintroducing the treated sample material to the blood stream of the patient.

REFERENCES:
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Schlom, J. et al., Hybridoma in Cancer Diagnosis and Treatment; Raven Press, New York, 1982, pp. 213-214.
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Foster et al., Manuscript No: 9034 submitted to Developmental Biology, Aug. 2, 1982, pp. 1-45.
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Foster et al., Virchows Arch, vol. 394, pp. 279-293, 1982.
Foster, Cancer Treatment Report, 9, 59-84, 1982.
Ludwig Institute for Cancer Research, Scientific Report 1981, pp. 22-33.

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