Novel monoclonal antibodies to human renin and hybridoma cells,

Details Novel monoclonal antibodies to human renin and hybridoma cells, Novel monoclonal antibodies to human renin and hybridoma cells,

1985-03-28

1988-10-25

Warden, Robert J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 68, 4351722, 435810, 424 858, 424 88, 436518, 436548, 436808, 436815, 530387, 530388, 530808, 935 89, 935 93, 935104, 935106, 935107, 935108, 935110, G01N 3353, G01N 33577, C12N 1500

Patent

active

047804017

ABSTRACT:
The invention relates to novel monoclonal antibodies having a high affinity for human renin, derivatives thereof, processes for the preparation of these antibodies and their derivatives, hybridoma cell lines that produce these antibodies, and to processes for the preparation of said hybridoma cells lines. The monoclonal antibodies according to the invention and their derivatives can be used for the qualitative and quantitative determination of human renin and structurally similar renin, for the purification of human renin and structurally similar renin and for the treatment of high blood pressure and cardiac insufficiency.

REFERENCES:
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Corvol et al, Chemical Abstracts, vol. 102(13) No. 108589n (1984).
Menard et al, Chemical Abstracts, vol. 103(7), No. 50128p (1984).
Michel, et al. Amer. Journal of Physiology, vol. 15, No. 3 (3/84) pp. F309.
Heterogeneity of Renin and Renin-Substrate (ed. M. P. Sambhi), Elsevier North Holland Inc., pp. 237-241 (1981)--Soubrier et al.
Pau et al, Clin. Sci. 61, 239 (1981).
H. Clin. Endocr. Met., 48, 1041 (1979)--Galen et al.
J. Hypertens., 2 (Suppl. 3), 275-278 (1984)--Menard et al.
Proc. Int. Symp. Radioimmunol., 6, 69-79 (1984)--Corvol et al.
D. Simon et al. J. Clin. Endocr. Met., vol. 53 (1981), pp. 453-455.
V. J. Dzau et al., Clin. and Exper. Hyper. A5 (1983), pp. 1207-1220.

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