Novel microorganism and method

Details Novel microorganism and method Novel microorganism and method

1983-01-18

1987-07-21

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

4351721, 4351723, 435849, 935 56, 935 73, C12P 1322, C12N 1500, C12R 119

Patent

active

046818529

ABSTRACT:
A method for producing phenylalanine comprising culturing novel strains of the bacteria Escherichia coli. The novel strains of E. coli are those in which inhibition of the enzyme DAHP synthease by phenylalanine, tyrosine or tryptophan is removed and inhibition of the enzyme chorismate mutase P-prephenate dehydratase by phenylalanine is removed and in which enhanced levels of production of the enzymes DAHP synthease, chorismate mutase P-prephenate dehydratase and shikimate kinase are achieved. The organism is preferably also modified to limit the production of alternate end products from chorismate.

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