Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1989-12-27
1992-02-04
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530327, A61K 3702, C07K 710, C07K 708
Patent
active
050861646
ABSTRACT:
The subject invention pertains to the use of recombinant PF4 (rPF4) as well as full length novel analogs (mutants) of rPF4, and peptide fragments thereof, to inhibit angiogenesis. rPF4, analogs, and certain fragments are shown to have utility for treating angiogenic diseases and for the inhibition of endothelial cell proliferation.
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Taylor, S., J. Folkman, (1982), "Protamine is an Inhibitor of Angiogenesis", Nature, 297:307-312.
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Osterman, D. G., G. L. Griffin, R. M. Senior, E. T. Kaiser, T. F. Deuel, (1982), "The Carboxyl-Terminal Tridecapeptide of Platelet Factor 4 is a Potent Chemotactic Agent for Monocytes", Biochem. and Biophys. Res. Comm., 107(1):130-135.
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Maione Theodore
Sharpe Richard J.
Cunningham T.
Moskowitz Margaret
Repligen Corporation
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