Chemical apparatus and process disinfecting – deodorizing – preser – Process disinfecting – preserving – deodorizing – or sterilizing – Using disinfecting or sterilizing substance
Patent
1988-08-09
1990-11-20
Warden, Robert J.
Chemical apparatus and process disinfecting, deodorizing, preser
Process disinfecting, preserving, deodorizing, or sterilizing
Using disinfecting or sterilizing substance
422 28, 435 2, 514833, 530385, A61L 218, A61L 220, C07K 1506
Patent
active
049717600
ABSTRACT:
It is well known that the transfusion of human blood and blood constituents, or the transplantation of corneas and sclerae, carries a substantial risk of transmission of AIDS and many other diseases. This disclosure describes a method of disinfecting certain blood constituents--particularly the red cells, platelets and proteins--or disinfecting corneal and scleral tissues, to make them safer for human transfusion or transplantation, while respectively maintaining their biologic or optical function. A sterilizing solution is prepared from, e.g., a commercially available disinfectant (such as LD.RTM. of Alcide Corporation) containing primarily lactic acid and sodium chlorite. Normal saline solution is used as diluent instead of distilled water. The blood constituent or cornea or sclera is exposed to the disinfectant for a time sufficient to inactivate or reduce the infectivity of disease agents. The normal-saline environment prevents or deters hemolysis of the red blood cells or damage to the corneal or scleral epithelium or endothelium, disruption of the platelets, or denaturation of the proteins. The blood cells or platelets (or both), or the cornea or sclera (or both) are then washed with normal saline solution until the disinfectant concentration is insignificant. Plasma proteins are precipitated out as with ammonium sulfate, resuspended and dialyzed to remove residual disinfectant and coagulant, and reconstituted. The blood constitutents or eye parts are then safe for human transfusion or transplantation.
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Johnston Jill
University of Southern California
Warden Robert J.
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