Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1986-09-08
1991-02-19
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530827, 530837, 530828, 424 851, 424 852, 424 854, 424 855, 424 856, 424 857, 514 2, 514 8, 514 21, 435 701, C07K 1500, A61K 3900
Patent
active
049945564
ABSTRACT:
A novel lymphokine and its production and uses are disclosed. The lymphokine is a glycoprotein with a molecular weight of 15,000.+-.2,000 daltons; isoelectric point pI, 4.5.+-.0.5; electrophoretic mobility Rf, 0.73.+-.0.05; cytotoxic on L 929 cell; and cytostatic on KB cell with or without human interferon-alpha. The lymphokine significantly inhibits in vivo the growth of malignant human tumors in cooperation with human interferon, therefore is useful in prophylactic and therapeutic treatment of human malignant tumors.
REFERENCES:
patent: 4758549 (1988-07-01), Mitsuhashi et al.
E. A. Carswell et al., Proceedings of the National Academy of Sciences of the U.S.A., vol. 72, No. 9, pp. 3,666-3,670 (1975).
Lymphokines, vol. 2, pp. 235-272, "Tumor Necrosis Factor", Edited by E. Pick, Published by Academic Press, Inc. (1981).
Ryuichi Aoki et al. Shin-Menekigaku Sosho, vol. 6, "Lymphokine", pp. 87-105 (1979), Published by Igaku-Shoin, Tokyo (With Partial Translation).
In Vitro Methods in Cell-Mediated Immunity, Edited by B. R. Bloom & P. R. Glade, Published by Academic Press, Inc. (1971).
Cellular Immunology, vol. 38, pp. 388-402 (1978).
Kurimoto Masashi
Mitsuhashi Masakazu
Draper Garnette D.
Kabushiki Kaisha Hayashibara Seibutsu Kagaku
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