Novel, long-duration treatment for glaucoma

Details Novel, long-duration treatment for glaucoma Novel, long-duration treatment for glaucoma

1988-03-24

1990-03-06

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Lymphokine

424 78, 514560, A61K 3120

Patent

active

049064673

ABSTRACT:
The present invention relates to a method of and composition for reducing intraocular pressure. The method comprises administering to a patient requiring such reduction of intraocular pressure a therapeutically effective amount of 12(R)-hydroxy-eicosa-5,8,10,14-tetraenoic acid (12(R)-HETE). The method of the present invention is particularly useful in treatment of all types of glaucoma. The method is also useful in lowering intraocular pressure in preparation for eye surgery, particularly for the removal of cataracts.

REFERENCES:
patent: 2934570 (1960-04-01), Goldberg et al.
patent: 3450821 (1969-06-01), Carstensen et al.
patent: 3461210 (1969-08-01), Fossel
patent: 4190669 (1980-02-01), Voorhees et al.
patent: 4584320 (1986-04-01), Rubin
N. Abraham et al., "Presence of Heme Oxygenase and NADPH Cytochrome P.sub.450 (c) Reductase in Human Corneal Epithelium," Invest. Opthalmol. Vis. Sci., 28, pp. 1464-1472 (1987).
M. Schwartzman et al., "Cytochrome P.sub.450 Dependent Metabolism of Arachidonic Acid in Bovine Corneal Epithelium," Biochem. Biophys. Res. Comm., 132, pp. 343-351 (1985) (Schwartzman I).
M. Schwartzman et al., "Cytochrome P.sub.450 -Dependent Arachidonate Metabolism in Corneal Epithelium: Formation of Biologically Active Compounds," Adv. Prostaglandin, Thrombox and Leuk. Res., 17, pp. 78-83 (1987) (Schwartzman II).
M. Schwartzman et al., "Cytochrome P450, Drug metabolizing Enzymes and Arachidonic Acid Metabolism in Bovine Ocular Tissues," Current Eye Res., 6, pp. 623-630 (1987) (Schwartzman III).
M. Schwartzman et al., "Identification of Novel Cornea Arachidonic Acid Metabolites: Characterization of Their Biological Activities," abstract Invest. Ophthalmol. Vis. Sci., vol. 28, Supp. 3, p. 328 (1987) (Schwartzman IV).
M. Schwartzman et al., "12(R)-HETE--A Cytochrome P.sub.450 -Dependent Arachidonate Metabolite That Inhibits Na.sup.+ -K.sup.+ -ATPase in the Cornea," Proc. Natl. Acad. Sci. (U.S.A.), vol. 84, pp. 8125-8129 (1987) (Schwartzman V).
M. Woolard, "Stereochemical Difference between 12-Hydroxy-5, 8, 10, 14-Eicosatetraenoic Acid in Platelets and Psoriatic Lesions," Biochem. Biophys. Res. Comm., 136, pp. 169-176 (1986).

Affiliated with

Also associated with

Rating

Novel, long-duration treatment for glaucoma does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel, long-duration treatment for glaucoma, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel, long-duration treatment for glaucoma will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-46482