Novel liposome composition for sustained release of steroidal dr

Details Novel liposome composition for sustained release of steroidal dr Novel liposome composition for sustained release of steroidal dr

1988-12-14

1991-08-27

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

424 11, 424 9, 514180, A61K 3722

Patent

active

050431650

ABSTRACT:
This invention relates to a novel, non-conventional liposome formulation for the sustained release and delivery of steroids. The formulation provides prolonged release of the drug, improved therapeutic ratio, lower toxicity, reduced systemic side effects and is stable for up to three months. The formulation is suitable for sustained delivery of steroid via inhalation, parenteral, intrathecal, intraarticular, topical, ophthalmic, and oral administration.

REFERENCES:
patent: 4224179 (1980-09-01), Schneider
patent: 4235871 (1980-11-01), Parahadjopoulos et al.
patent: 4515736 (1985-05-01), Deamer
patent: 4693999 (1987-09-01), Axelsson et al.
patent: 4746516 (1988-05-01), Moro et al.
patent: 4780455 (1988-10-01), Lieberman et al.

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