Novel lectins derived from bacterial pili

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.

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530418, 530825, 424 92, 435320, A61K 3702, A61K 39108, A61K 39112, C12N 100

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active

048016900

ABSTRACT:
A lectin derived from the pili of piliated organisms, said lectin being non-covalently bindable to the pilus rod protein of said pili and separable therefrom by the action of aqueous sodium dodecyl sulfate, possessing a single binding site for binding to mammalian erythrocyte ghosts.

REFERENCES:
patent: 4343792 (1982-08-01), Gouet et al.
Salit et al., Journal of Experimental Medicine 146, pp. 1160-1181 (1977).
Eshdat et al., Biochemical and Biophysical Research Communications 85 (4), pp. 1551-1559 (1978).
Olafson et al., Infection and Immunity 48(2), pp. 336-342 (1985).
Matsui et al., Journal of Biochemistry 97, pp. 399-408 (1985).
Sharon et al. CIBA Foundation Symposium 80, pp. 119-141.
Eshdat et al, Methods in Enzymology 83, pp. 386-391 (1982).

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