Novel intermediates of cephalosporins and process for producing

Details Novel intermediates of cephalosporins and process for producing Novel intermediates of cephalosporins and process for producing

1984-09-26

1987-06-16

Marantz, Sidney

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540226, 540227, 540221, C07D50138, C07D50140, C07D50146

Patent

active

046737383

ABSTRACT:
This invention relates to novel 7-(substituted or unsubstituted amino)-3-substituted methyl-.DELTA..sup.3 -cephem-4-carboxylic acids in which a substituted or unsubstituted 1,2,4-triazolyl or 2-(1,2,3,4-tetrazolyl) group attaches to the exomethylene group at the 3-position of the cephem ring through a carbon-nitrogen bond. These cephalosporins are useful intermediates for producing various novel cephalosporins. Also, this invention concerns a process for producing a compound represented by the formula: ##STR1## which comprises reacting a compound represented by the formula: ##STR2## with an optionally substituted triazole or tetrazole in the presence of an acid or a complex of the acid in an organic solvent at 0.degree. to 80.degree. C.

REFERENCES:
patent: 3821206 (1974-06-01), Cowley
patent: 3859282 (1975-01-01), Cheng
patent: 4143166 (1979-03-01), Takaya
patent: 4148997 (1979-04-01), Haviv
patent: 4317907 (1982-03-01), Saikawa
patent: 4343937 (1982-08-01), Christensen
Elderfield--I and II "Heterocyclic Compounds" vol. 7 and 8, pp. 456 and 457, 8 and 9, Wiley & Sons (1957).
Tetrahedron Letters, No. 30, 2625-2628, 1974.
J. Am. Chem. Soc., 62, 2385 (1940).
J. Am. Chem. Soc., 78, 2318 (1956).

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