Novel intermediates for synthesis of trichostatic acid or tricho

Details Novel intermediates for synthesis of trichostatic acid or tricho Novel intermediates for synthesis of trichostatic acid or tricho

1989-02-22

1990-08-07

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

556413, 556423, 562459, C07C22900

Patent

active

049469991

ABSTRACT:
The present invention relates to a process for preparing trichostatic acid represented by the following formula [14] ##STR1## by oxidizing (E,E)-7-(4'-dimethylaminophenyl)-7-hydroxy-4,6-dimethylhepta-2,4-dienoic acid represented by the following formula [13]: ##STR2## and a process for preparing trichostatin A represented by the following formula [15]: ##STR3## by allowing to react trichostatic acid with amine.

REFERENCES:
patent: 3867434 (1975-02-01), Diamond
patent: 3868406 (1975-02-01), Siddall
patent: 4218378 (1980-08-01), Bundy
patent: 4218478 (1980-08-01), Omura
patent: 4243819 (1981-01-01), Henrick et al.
The Total Synthesis of (.+-.)-Trichostatin A, by Ian Fleming et al., Tetrahedron, vol. 39, No. 6, 1983, pp. 841-846.
Methoden Der Organishen Chemie (Houben-Weyl) vol. X/1, 1971, pp. 1229-1231 and 1271-1273.

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