Novel imidazobenzoxazines

Details Novel imidazobenzoxazines Novel imidazobenzoxazines

1977-08-01

1979-03-20

Randolph, John D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544101, 544105, A61K 31535, C07D49802

Patent

active

041454197

ABSTRACT:
Novel imidazobenzoxazines of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, nitro, NH.sub.2 and a protected amino Z is selected from the group consisting of --COOR, and ##STR2## R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, ##STR3## alkali metal, alkaline earth metal, magnesium, aluminum and nitrogen bases, n is 1,2 or 3, R.sub.1 and R.sub.2 individually are selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms and taken together with the nitrogen atom to which they are attached form a saturated heterocyclic ring of 4 to 6 carbon atoms optionally interrupted by another heteroatom which may optionally be substituted with alkyl of 1 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having antiallergic and bronchodilatory activity and their preparation.

REFERENCES:
patent: 3929783 (1975-12-01), Krapcho et al.
Pyatin et al., Chemical Abstracts, vol. 74, Abst. No. 112019x, (1971).
Lowy et al., An Introduction to Organic Chemistry, 6th Ed., Frontispage and p. 213, John Wiley & Sons, Inc., N. Y., (1945).

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