Novel hydroxide mediated FK-506 rearrangement process

Details Novel hydroxide mediated FK-506 rearrangement process Novel hydroxide mediated FK-506 rearrangement process

1989-09-05

1990-04-24

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540452, C07D49816, C07D49818

Patent

active

049202189

ABSTRACT:
A process is described involving an alkaline rearrangement of FK-506 producing a new decarbonylated 22-membered macrocycle rearrangement derivative of FK-506, i.e. C.9, nor-keto FK-506.

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