Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1977-02-17
1978-04-11
Evans, Joseph E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
260295AM, 2603322C, 2603409R, 2603473, 2605005H, 424263, 424275, 424282, 424285, A61K 31185, C07C 8310
Patent
active
040839966
ABSTRACT:
A novel compound having the general formula: ##STR1## wherein R.sub.1 is a residual group selected from the group consisting of substituted phenyl, carbonoylaminophenyl and heterocyclic groups, and R.sub.2 is hydrogen or methyl group, and its salts of a pharmacologically acceptable base and a novel medicament containing the compound or its salt mentioned above as a principal component; and the compound and the salt thereof having superior effect for the treatment of urolithiasis and the pyelonephrosis by exhibiting a strong urease inhibitory action, a high transfer rate into the urine and a low toxicity.
REFERENCES:
patent: 3728380 (1973-04-01), Johnson et al.
Wald et al., "Chemistry and Industry", Jan. 14, 1967, pp. 71-73.
Buraczewski et al., "Bulletin de l'Academie Polonaise des Sciences", Serie des Sciences Chimiques, vol. XII, No. 14, 1964, pp. 773-779.
Munakata Keiichi
Tanaka Satoru
Eisai Co. Ltd.
Evans Joseph E.
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