Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1989-08-04
1991-01-29
Shah, Mukund J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544363, 546164, 546167, 546180, C07D41300, C07D40100, C07D21500, C07D21518
Patent
active
049888102
ABSTRACT:
Novel enantiomeric and diastereoisomeric forms of decahydroquinolines of the formula ##STR1## wherein R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom to which they are connected from a 5 to 6 member heterocycle optionally including another heteroatom and optionally substituted, A is selected from the group consisting of --(CH.sub.2).sub.n -- and alkylene substituted with an alkyl and having 2 to 8 carbon atoms, n is an integer from 0 to 5, Z is selected from the group consisting of optionally substituted phenyl, naphthyl indenyl, monocyclic heterocycle of 5 to 6 members and a bicyclic heterocycle all being unsubstituted or substituted by one or more substituents and their non-toxic, pharmaceutically acceptable acid addition salts and quaternary ammonium salts having central analgesic properties.
REFERENCES:
patent: 4011229 (1977-03-01), Curran et al.
patent: 4145435 (1979-03-01), Szmuskovicz
patent: 4173636 (1979-11-01), Prost
patent: 4359476 (1982-11-01), Kaplan et al.
Clemence Francois
Delevallee Francoise
Fortin Michel
Le Martret Odile
Roussel Uclaf
Shah Mukund J.
Ward E. C.
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