Novel hydrocortisone derivative

Details Novel hydrocortisone derivative Novel hydrocortisone derivative

1979-03-26

1981-09-22

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 500

Patent

active

042909627

ABSTRACT:
17.alpha.-butyryloxy-11.beta.-hydroxy-21-propionyloxy-4-pregnen-3,20-dione, i.e., hydrocortisone 17-butyrate 21-propionate of the present invention is prepared by acylating hydrocortisone 17-butyrate with propionic acid anhydride or halide. The compound of the present invention has excellent anti-inflammatory effect, percutaneous absorption and less side effect.

REFERENCES:
patent: 3152154 (1964-10-01), Ercoli et al.
patent: 3312590 (1967-04-01), Elko et al.
patent: 3312591 (1967-04-01), Elks et al.
patent: 3422193 (1969-01-01), Shapiro et al.

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