Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1983-12-21
1990-01-09
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
530351, 435 6951, A61K 4502, C07K 1300, C07K 1526, C12P 2100
Patent
active
048927430
ABSTRACT:
The invention features a novel hybrid interferon species that comprises a chain of 161 and/or 162 amino acids. The hybrid is novel not only for its new structure, but also because the hybrid comprises a shortened or truncated segment of alpha interferon, and hence, an entirely new interferon species which is not occurring in nature.
REFERENCES:
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Goeddel et al., (1980), Nucleic Acids Research, vol. 8, No. 18, pp. 4057-4074.
Weissmann, C. (1981) "The Cloning of Interferon and Other Mistakes, in Interferon 1981", vol. 3, p. 101.
Roberts, T. M. and Gail D. Lauer, 1979, "Maximizing Gene Expression on a Plasmid Using Recombination in Vitro", Methods in Enzymology, 68: pp. 473-482.
Rehberg et al., "Specific Molecular Activities of Recombinant and Hybrid Leukocyte Interferons," J. Biol. Chem., vol. 257 (19), pp. 11497-11502 (1982).
Weber and Weismann, "Formation of Genes Coding for Hybrid Proteins by Recombination Between Related, Cloned Agents in E. Coli," Nucleic Acids Research, vol. 11 (16), pp. 5661-5669 (1983).
Pestka, "The Human Interferons-From Protein Purification and Sequences to Cloning and Expression in Bacteria: Before, Between and Beyond," Archives of Biochem. and Biophys., vol. 221(1), pp. 1-37 (1983).
Pestka, "The Purification and Manufacture of Human Interferons," Scientific American, vol. 249 (2), pp. 29-35 (1983).
Franke et al., "Carboxyterminal Region of Hybrid of Leukocyte Interferons Affects Anti-Viral Specificity," DNA, vol. 1 (3), pp. 223-230 (1982); see C.A. 97: 176172z.
P. K. Weck et al., Antiviral Activities of Hybrids of Two Major Human Leukocyte Interferons, Nucleic Acids Research, vol. 9, No. 22 (1981), pp. 6153-6166.
Leibowitz Paul J.
Ryan Michael J.
Hazel Blondel
Majka Joseph T.
Nowak Henry P.
Rosen Gerald S.
Schering Corporation
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