Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1987-06-22
1991-02-05
Teskin, Robin L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 691, 4351723, 4353201, 4352523, 43525233, 935 10, 536 27, 530350, 530351, C12P 2100, C12N 1500, C07H 1512
Patent
active
049904558
ABSTRACT:
A human TNF polypeptide mutant having an amino acid sequence of modified human TNF polypeptide, a DNA having a base sequence encoding the above human TNF polypeptide mutant and a method of producing the above human TNF polypeptide mutant by culturing a host transformed with a vector having inserted therein the above DNA. The above human TNF polypeptide mutant is soluble and has antitumor activity.
REFERENCES:
patent: 3723249 (1973-03-01), Kubota et al.
patent: 4775623 (1988-10-01), Katsumata et al.
Agricultural & Biological Chemistry, 36, 1675-1684 (1972).
Journal of General and Applied Microbiology 19, pp. 339-352 (1973); 16, pp. 373-391 (1970) (Kubota).
Shirai et al., Nature, vol. 313, Feb. 28, 1985, pp. 803-806.
Yamada et al., Journal of Biotechnology, vol. 3, 1985, pp. 141-153.
Furuta Ryuji
Kawashima Hitoshi
Kotani Hirotada
Nakata Katuhisa
Yamagishi Junichi
Dainippon Pharmaceutical Co., Ltd.
Teskin Robin L.
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