Novel human proinsulin C-peptide derivatives

Details Novel human proinsulin C-peptide derivatives Novel human proinsulin C-peptide derivatives

1974-07-15

1976-04-27

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 12, 424178, C07C10352, A61K 3726

Patent

active

039534189

ABSTRACT:
A peptide having an amino acid sequence of Arg-Arg-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gl y-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-Lys-Arg; Tyr-Arg-Arg-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pr o-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-Lys-Arg; or Tyr-Arg-Arg-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gl y-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-Lys-Arg; and the N.sup..epsilon. formyl-Lys derivative thereof.

REFERENCES:
patent: 3715434 (1973-02-01), Mende
Dreier et al: Chem. Abstr., 75:95273b (1971).
Glover et al: Chem. Abstr., 66:72443g (1967).
Ko et al: Eur. J. Biochem., 20, 190-199, (1971); cited in Chem. Abstr., 75:30159z.
Yanaihara et al: Chem. Pharm. Bull., 18, 417-420, (1970); cited in Chem. Abstr., 72:90858z.

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