Novel human physiologically active polypeptide

Details Novel human physiologically active polypeptide Novel human physiologically active polypeptide

1984-04-06

1989-11-07

Teskin, Robin L.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Enzymatic production of a protein or polypeptide

530350, 530351, 530828, 43525233, 435 70, 4351723, 435255, 435320, 4352402, 435948, 536 27, 514 2, 514 12, 514 21, 935 9, 935 11, 935 56, 935 73, C12P 2100, C12N 1500, C12N 120, C07H 1512

Patent

active

048792268

ABSTRACT:
A human physiologically active polypeptide, human Tumor Necrosis Factor (human TNF), comprising a specific amino acid sequence of 155 amino acid residues. The base sequence of the DNA coding for the human TNF has been determined using rabbit TNF cDNA. The human TNF can be advantageously produced on a large scale by recombinant DNA technique. The human TNF of the present invention has been found to be excellent in inducing necrosis of tumors with no toxic effect upon the normal tissues of the living body.

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