Novel human interferon-.gamma. polypeptide derivative

Details Novel human interferon-.gamma. polypeptide derivative Novel human interferon-.gamma. polypeptide derivative

1985-07-10

1990-02-06

Hazel, Blondel

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

424 855, 435 6951, C07K 1300, C07K 1526, A61K 4502

Patent

active

048989312

ABSTRACT:
Disclosed is a novel derivative of human IFN-.gamma. polypeptide wherein certain amino acids of human IFN-.gamma. polypeptide are removed and certain amino acids other than said amino acids are replaced with other amino acids. The derivatives have high IFN-.gamma. activity and are expected to be useful as drugs such as anti-viral and anti-tumor agents.

REFERENCES:
patent: 4457867 (1984-07-01), Ishida
patent: 4727138 (1988-02-01), Goeddel et al.
Shepard et al, Nature, vol. 294, pp. 563-565, 1981.
K. Alton et al., "Production, Characterization and Biological Effects of Recombinant DNA Derived Human IFN-.alpha. and IFN-.gamma. Analogs", The Biology of the Interferon System 1983, Elsevier Science Publishers B.V., pp. 119-127.
B. Rubin et al., Proc. Natl. Acad. Sci., USA, vol. 77, No. 10, pp. 5928-5932 (Oct. 1980).
P. Gray et al., Nature, vol. 295, pp. 503-508 (Feb. 11, 1982).
R. Devos et al., Nucleic Acids Research, vol. 10, No. 8 (1982).
A. Franke et al., DNA, vol. 1, No. 3, pp. 223-230 (1982).
R. King et al., J. Gen. Virol., 64, 1815-1818 (1983).
Nishi et al., DNA, vol. 2, No. 4, pp. 265-273 (1983).
Itoh et al., DNA, vol. 3, No. 2, pp. 157-165 (1984).
Gray et al., Proc. Natl. Acad. Sci. USA, vol. 80, pp. 5842-5846 (1984).

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