Novel human growth hormone like protein HGH-V encoded in the hum

Details Novel human growth hormone like protein HGH-V encoded in the hum Novel human growth hormone like protein HGH-V encoded in the hum

1984-03-01

1987-05-12

Kight, John

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Hormones, e.g., prolactin, thymosin, growth factors, etc.

530808, 530825, 530350, 435 68, 435 70, C07K 1300, C12P 2102

Patent

active

046651608

ABSTRACT:
A novel non-allelic human growth hormone variant protein is disclosed. The structure of the protein is determined and the protein product is produced by recombinant DNA methods.

REFERENCES:
patent: 4342832 (1982-08-01), Goeddel et al.
Goeddel et al., Direct Expression in E. coli, of a DNA Sequence Coloring for Human Growth Hormone, Nature vol. 281, 1979, p. 544.
Pavlakis et al., Expression of Two Human Growth Hormone Genes in Monkey Reels Infected by Simian Virus 40 Recombinants, PNAS 78(12)1981, pp. 7398-7402.
Lewis et al., A Naturally Ocurring . . . Hormone, J.BC 263(8), 1978, pp. 2679-2687.
Lewis et al., The 20,000-Dalton Variant . . . Deletions, Biochem Biophys.Res.Comm. 92(2), 1980, pp. 511-516.
Seeburg, The HGH . . . Polypeptide Hormone, Chem. Abst. No. 12288m, (1982-DNA 1(3) pp. 239-249).
Ross et al., CA No. 174038g (Horm. Drug . . . Horm 1982, pp. 313-318).
Hearn et al., CA No. 119840n (J. Lig. Chromatogs 1983, 6(2), pp. 215-228).
Seeburg et al.; Nature 270, (1977) pp. 486-494.
Amino-Acids, Peptides and Proteins, The Chemical Society, Specialist Periodical Reports: vol. 5, p. 340; vol. 8, pp. 289-290, p. 296; vol. 11, p. 371.
Hamer et al.: Nature 281, 35 (1979).
Helling et al.: in Genetic Engineering, Chakrabarty (ed.) CRC Press, (1978) pp. 1-30.
Fiddes et al.: Proc. Natl. Acad. Sci. USA 76, 4294 (1979).

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