Novel heparin derivative, method for production thereof, and met

Details Novel heparin derivative, method for production thereof, and met Novel heparin derivative, method for production thereof, and met

1980-09-02

1982-05-25

Silverberg, Sam

Coating processes

Medical or dental purpose product; parts; subcombinations;...

Particulate or unit-dosage-article base

424183, 536 21, A01N 102

Patent

active

043316972

ABSTRACT:
A heparin derivative in which at least 0.5% of the entire hydroxyl groups of heparin are in the form of an ester of the following formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each represent a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; a method for producing aforesaid heparin derivative which comprises reacting heparin with a halide or anhydride of an unsaturated carboxylic acid of the formula ##STR2## wherein R.sub.1, R.sub.2 and R.sub.3 are the same as defined above; and a method for imparting antithrombotic activity to a biomedical material, which comprises treating that surface of the biomedical material which makes contact with the blood with actinic light in the presence of aforesaid heparin derivative.

REFERENCES:
patent: 3211617 (1965-10-01), Bucourt
patent: 3835112 (1974-09-01), Mardiquian
patent: 3844989 (1974-10-01), Harumigs

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