Novel halogenopregnadienes and process for the manufacture there

Details Novel halogenopregnadienes and process for the manufacture there Novel halogenopregnadienes and process for the manufacture there

1978-06-20

1980-09-09

Roberts, Elbert L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

26023955D, 26039745, 26023955R, A61K 3158

Patent

active

042217865

ABSTRACT:
The invention relates to the preparation of polyhalogenated pregnane derivatives of the formula ##STR1## wherein X represents fluorine or chlorine and R a free or esterified hydroxyl group or chlorine. The new compounds display a high antiinflammatory activity. No side action on the thymus, the body weight or the adrenals can be detected at the therapeutic dose when the compounds are administered topically. The new compounds are therefore particularly suitable for use as medicaments in dermatology.
The new compounds can be prepared according to methods known in the art, e.g. by introducing the chlorine atom in 2-position of corresponding compounds which are non chlorinated in this position, or by the introduction of the halogen atom in 9-position starting from the 9,11.beta.-epoxide or the 9,11-dehydro-compound or by acetonization of the 16,17-dihydroxy group or by replacing a 21-hydroxy group by chlorine.

REFERENCES:
patent: 2865936 (1958-12-01), Schneider et al.
patent: 3197469 (1965-07-01), Fried et al.
patent: 3678034 (1972-07-01), Laurent et al.
patent: 3687942 (1972-08-01), Anner
patent: 3740392 (1973-06-01), Heider et al.

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