Novel Guanidinium aspartates

Details Novel Guanidinium aspartates Novel Guanidinium aspartates

1989-11-17

1990-09-25

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514563, 562449, A61K 31205

Patent

active

049593943

ABSTRACT:
The L-arginine salt of N-(D)-{[2-(2,6-dichlorophenylamino}phenyl]acetyl]aspartic acid, represented by the formula ##STR1## in which AmH .sym. represents the cation derived from L-arginine Am of the formula ##STR2## and its hydrates exhibit and excellent water-solubility and a physiologically favorable pH value and also a pleasant taste in aqueous solutions and are therefore excellently suitable for enternal and parenteral forms of administration. It is manufactured by reacting L-arginine with D-{[2-(2,6-dichlorophenylamino)phenyl]-acetyl}aspartic acid.

REFERENCES:
patent: 4250192 (1981-02-01), Sallmann et al.
patent: 4279926 (1981-07-01), Bruzzese et al.
patent: 4440787 (1984-04-01), de Vincentiis

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