Novel glycoproteins from bovine cartilage

Details Novel glycoproteins from bovine cartilage Novel glycoproteins from bovine cartilage

1979-04-26

1981-01-06

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 95, 424177, C07G 700

Patent

active

042435820

ABSTRACT:
Two high purity glycoprotein components each having a molecular weight of about 65,000 daltons and having activity as trypsin inhibitors and inhibitors of endothelial cell growth are obtained from bovine cartilage extract. A guanidine hydrochloride extract of bovine cartilage is subjected to ammonium sulfate salt fractionation, DEAE-Sephadex ion exchange chromatography, SP-Sephadex ion exchange chromatography and Con A-Sepharose affinity chromatography to isolate these glycoproteins in a high purity preparation.

REFERENCES:
patent: 4002572 (1977-01-01), te Nijenhuis
patent: 4042457 (1977-08-01), Kuettner et al.
patent: 4108849 (1978-08-01), Thomas
patent: 4154821 (1979-05-01), Drouet et al.
patent: 4190573 (1980-02-01), Zwisler et al.
Kuettner et al., Experientia, vol. 30, pp. 595-597 (1974).
Keuttner et al., Biochem Biophys. Res. Comm., vol. 72, No. 1, pp. 40-46 (1976).
Langer et al., Science, vol. 193 (1976), pp. 70-72.

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