Novel glycopeptide antibiotics

Details Novel glycopeptide antibiotics Novel glycopeptide antibiotics

1987-01-14

1990-08-07

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530322, 435 713, C07K 764, C07K 900

Patent

active

049469410

ABSTRACT:
The compounds of the formula: ##STR1## wherein R is ##STR2## or H, wherein X is NH.sub.2 and Y is CH.sub.3 ; or X is OH and Y is H, and their pharmaceutically acceptable salts. The compounds have a potent activity against gram-positive bacteria, especially, methicillin-resistant bacteria.

REFERENCES:
patent: 4495179 (1985-01-01), Hoehn et al.
patent: 4547488 (1985-10-01), Merkel
patent: 4717714 (1988-01-01), Boeck et al.
patent: 4804534 (1989-02-01), Riva et al.

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