Novel excipient and pharmaceutical composition containing the sa

Details Novel excipient and pharmaceutical composition containing the sa Novel excipient and pharmaceutical composition containing the sa

1978-01-31

1979-06-26

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

A61K 4700

Patent

active

041593456

ABSTRACT:
An excipient for use in manufacture of tablets, capsules, powders, microgranules and granules which consists essentially of a microcrystalline cellulose having an average degree of polymerization of 60 to 375 and obtained through acid hydrolysis or alkaline oxidative degradation of a celulosic substance selected from linters, pulps and regenerated fibers, said microcrystalline cellulose being a white cellulosic powder having an apparent specific volume of 1.6 to 3.1 cc/g, a repose angle of 35.degree. to 42.degree., a 200-mesh sieve residue of 2 to 80% by weight and a tapping apparent specific volume of at least 1.4 cc/g and a pharmaceutical composition comprising a pharmaceutically active ingredient and the excipient. This excipient has improved flowability and moldability or compressibility whereby excellent pharmaceutical preparations may be easily provided. In addition, pharmaceutical compositions obtained using such excipient are excellent in various pharmaceutical characteristics such as rate of disintegration, rate of dissolution, etc.

REFERENCES:
patent: 3146168 (1964-08-01), Battista
patent: 3966899 (1976-06-01), Nakai et al.
patent: 4001434 (1977-01-01), Nakai et al.
Bolhuis et al. Pharmaceutisch Weekblad 108(22): 469-481, Jun. 1973.

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