Novel ethyl benzylphosphinate derivatives, process for productio

Details Novel ethyl benzylphosphinate derivatives, process for productio Novel ethyl benzylphosphinate derivatives, process for productio

1985-05-22

1986-08-19

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514212, 514231, 514321, 514367, 546 24, 544 96, 548111, 548113, A61K 31675, C07F 965

Patent

active

046070311

ABSTRACT:
An ethyl benzylphosphinate derivative represented by the general formula (I) ##STR1## wherein Y represents a hydrogen or fluorine atom, X represents a methylene group or an oxygen atom, and n is 2, 3 or 4.
The said compounds can be produced by reacting a compound represented by the following formula (II) ##STR2## wherein Y is as defined above, with a compound represented by the following formula (III) ##STR3## wherein X and n are as defined, and M is an alkali metal atom, in an inert medium. These compounds are useful as a calcium antagonist.

REFERENCES:
patent: 4232010 (1980-11-01), Tsukamoto et al.
patent: 4434162 (1984-02-01), Tsukamoto et al.

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