Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1989-06-13
1991-07-30
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
552626, 540109, 514182, A61K 31565, C07J 100
Patent
active
050360620
ABSTRACT:
The present invention concerns novel compounds having the general formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are selected form the group consisting of hydrogen or lower alkyl having 1-4 carbon atoms, wherein R.sup.2 and R.sup.3 together with the N atom can also form a ring having 2-5 carbon atoms and wherein n is 0, 1 or 2, and pharmaceutically acceptable salts thereof.
The compounds according to the invention are useful as anticancer agents.
REFERENCES:
patent: 3299104 (1967-01-01), Fex
patent: 4443440 (1984-04-01), Anderson
patent: 4584136 (1986-04-01), Yoshida et al.
patent: 4615835 (1986-10-01), Eisenbrand et al.
Niculescu-Duvaz et al., "New N-yperites of the . . . ", CA 68:29354h (1968).
Burger, A., "A Guide to Drug Design", John Wiley & Sons, p. 15, 1984.
Gunnarsson Per-Olov G.
Hansen Bertil V.
Johansson Sven-.ANG.ke
Mollberg Henri R.
Chang Celia
Ivy C. Warren
Pharmacia AB
Philpitt Fred
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