Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1980-06-16
1981-07-07
Phillips, Delbert R.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2603262, 2603264, 26032647, 26032648, 560 24, 560 32, 560159, 560169, 564136, 564152, 564153, 564159, C07C10352, C07D20724
Patent
active
042773954
ABSTRACT:
Compounds of the following general formula are irreversible inhibitors of pancreatic elastase: ##STR1## wherein M is hydroxy, lower alkoxy, benzyloxy or --NY.sub.1 Y.sub.2 wherein each of R.sub.4 and R.sub.5 is hydrogen or lower alkyl; R is CF.sub.3, CHF.sub.2 or CH.sub.2 F; R.sub.1 is straight or branched lower alkyl; R.sub.2 is defined the same as R.sub.1 or is benzyl; R.sub.30 is CHO, carbobenzoxy, tert-butoxycarbonyl, benzoyl or lower alkanoyl; X is pro, ala or leu and Y and Z together form a single bond; or Y-X is ala-pro, ala-ala or ala-leu and Z forms a single bond; and Z-Y-X is ala-ala-pro, ala-ala-ala or pro-ala-leu.
REFERENCES:
patent: 4176116 (1979-11-01), Hassall et al.
Bey Philippe
Metcalf Brian W.
Wiseman Jeffrey S.
Conte Salvatore R.
Kolano John J.
McDonald Raymond A.
Phillips Delbert R.
Richardson-Merrell Inc.
LandOfFree
Novel enzyme inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Novel enzyme inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel enzyme inhibitors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-193219