Novel dihydropyridine derivatives

Details Novel dihydropyridine derivatives Novel dihydropyridine derivatives

1987-02-24

1991-07-23

Rosen, Sam

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514315, 514336, 514343, 546321, 546263, 546275, 546283, 546284, 546256, A61K 31435

Patent

active

050343955

ABSTRACT:
Dihydropyridine derivatives and salts thereof represented by the general formula, ##STR1## which possess excellent calcium antagonist effect, hypotensive effect, platelets aggregation inhibitory effect, phosphodiesterase inhibitory effect, calmodulin inhibitory effect and peroxidized lipid lowering effect, and thus dihydropyridine derivatives and salts thereof are useful as a coronary blood flow improving agent such as coronary vasodilator, hypotensive agent, prophylaxis and treating agents for thrombosis, phophodiesterase inhibitory agent, peroxidized lipid metabolism lowering agent, anti-inflammatory agent and others.

REFERENCES:
patent: 3664627 (1972-02-01), Bossert
patent: 3905970 (1975-09-01), Bossert
patent: 3985758 (1976-10-01), Minakami
patent: 4044141 (1977-08-01), Bossert
patent: 4393070 (1983-07-01), Sato
patent: 4430333 (1984-02-01), Campbell
patent: 4532248 (1985-07-01), Franckowiak
patent: 4578395 (1986-03-01), Yamaguchi
patent: 4622332 (1986-11-01), Wehinger
patent: 4656181 (1987-04-01), Sunkel
patent: 4672068 (1987-06-01), Kutsuma

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