Novel derivatives of N-(3,4,5-trimethoxy cinnamoyl)piperazine an

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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260250BN, C07D24102, C07D40306

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active

040296504

ABSTRACT:
Compounds having the formula ##STR1## in which R.sub.1 is alkyl having no more than 4 carbon atoms and R.sub.2 is dimethoxyphenylethyl or ##STR2## is piperidino, heptamethyleneimino or 1,2,3,4-tetrahydroisoquinolino. The compounds are prepared by condensing N-(3,4,5-trimethoxy cinnamoyl)N'-(carboxymethyl) piperazine with ##STR3## The compounds possess peripheral, coronary and cerebral vasodilatory properties and an antihypertensive property.

REFERENCES:
patent: 3634411 (1972-01-01), Fauran et al.
patent: 3639476 (1972-02-01), Eberle et al.
patent: 3753984 (1973-08-01), Fauran et al.

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