Novel derivatives of daunomycin

Details Novel derivatives of daunomycin Novel derivatives of daunomycin

1979-08-20

1981-03-17

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424177, 53617A, C07C10352, A61K 3700, C07G 1100

Patent

active

042566320

ABSTRACT:
The present invention relates to novel derivatives of the anthracycline type anticancer drug daunomycin which are characterized by improved anticancer activity and by reduced toxicity compared with daunomycin itself. The novel compounds are amino acid or peptidyl derivatives of daunomycin. The invention further relates to pharmaceutical compositions containing such derivatives as active ingredients.

REFERENCES:
patent: 3658786 (1972-04-01), Albrecht et al.
patent: 3686163 (1972-08-01), Arcamone et al.
patent: 4039663 (1977-08-01), Arcamone et al.
patent: 4046878 (1977-09-01), Patelli et al.
patent: 4107423 (1978-08-01), Arcamone et al.
Y. Levin, et al., Chem. Abstr. 90, (1979), 179962y.
H. Kikuchi, et al., Biological Abstr. 62, 44426.

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