Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Plant proteins – e.g. – derived from legumes – algae or...
Patent
1987-04-10
1991-01-15
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Plant proteins, e.g., derived from legumes, algae or...
530350, 530379, 530396, 530397, 530412, 530416, 530417, C07K 1510, C07K 302, C07K 320, C07K 322
Patent
active
049855417
ABSTRACT:
Purified cytotoxic proteins for use within therapeutic compositions are disclosed. The proteins inhibit protein synthesis in vitro, exhibit abortifacient activity in mice, and contain proline residues with equivalent positions at residue 43 and residue 46 in ricin A-chain. A method for preparing such a cytotoxic protein from the tissue of Trichosanthes kirilowii is also disclosed. The proteins may also be used within a method for inhibiting protein synthesis in selected cells.
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Kindsvogel Wayne R.
Maraganore John M.
Kushan Jeff
Moskowitz Margaret
ZymoGenetics Inc.
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