Novel cystine compounds, their preparation and use

Details Novel cystine compounds, their preparation and use Novel cystine compounds, their preparation and use

1987-11-02

1989-01-31

Lieberman, Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 19, 530531, 540454, 548535, 562557, A61K 3700, C07C10300

Patent

active

048015792

ABSTRACT:
Novel cystine compounds of the general formula I are proposed wherein the independently of one another each represent a, preferably natural, L-amino acid, in particular glycine, alanine, proline, threonine, serine, valine, arginine, lysine or ornithine; the R.sub.1 independently of one another each stand for an acyl group of an organic acid with 2 to 5 carbon atoms, preferably for acetyl-, propionyl-, succinyl- or hydroxysuccinyl- or for a, preferably natural, L-amino acid which via its carboxylic group is linked amide-like to the amino group of the amino acid AS, the amino acids indicated as preferred for AS also being preferred for the amino acids of R.sub.1, or the two R.sub.1 together form the acyl group of an organic dicarboxylic acid, preferably the succinic or malic group; and the R.sub.2 independently of one another each are an alkoxy group with 1 to 4 carbon atoms, preferably methoxy or ethoxy, the hydroxy group, where in case of the meaning of R.sub.2 =OH the carboxylic group(s) are each present as such or as an inorganic or organic salt, preferably with NaOH or KOH, organic bases or basic amino acids such as L-lysine, L-ornithine, L-arginine or L-histidine, or the radical of a further amino acid bound via an amide group, the carbocylic group(s) of the amino acid optionally also having the form of an inorganic or organic salt; further processes for their preparation as well as nutrient compositions formed therewith.

REFERENCES:
patent: 3875136 (1975-04-01), Kamber
patent: 4325943 (1982-04-01), Natarajan

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