Novel cyclopropyl squalene derivatives and their use as inhibito

Details Novel cyclopropyl squalene derivatives and their use as inhibito Novel cyclopropyl squalene derivatives and their use as inhibito

1990-03-22

1991-09-24

Mars, Howard T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568666, C07C 4318, C07C 4315, C07C 43188, A61K 3156

Patent

active

050515349

ABSTRACT:
The present invention relates to a group of compounds which are novel squalene derivatives containing the cyclopropyloxy functionality and which act to inhibit the synthesis of cholesterol in mammals and in fungi.

REFERENCES:
patent: 2330979 (1943-10-01), Krantz et al.
patent: 4891367 (1990-01-01), Angelastro et al.
Sen et al, J. Am. Chem. Soc., 1989, 111, 1508-1510.
S. E. Sen et al., Trisnorsqualene Cyclopropylamine: A Reversible, Tight-Binding Inhibitor of Squalene Epoxidase, Am Chem. Soc., 111(23), Nov. 8, 1989.
F. R. Taylor et al., 24,25-Epoxysterol Metabolism in Cultured Mammalian Cells and Repression of 3-Hydroxy-3-Methylglutaryl-CoA Reductase, J. Biol. Chem., 261(32), 15039-44 (11/86).
L. Cattel et al., The Squalene-2,3-Epoxide Cyclase as a Model for the Development of New Drugs, Lipids, 21(1), 31-38 (1986).

Affiliated with

Also associated with

Rating

Novel cyclopropyl squalene derivatives and their use as inhibito does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel cyclopropyl squalene derivatives and their use as inhibito, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel cyclopropyl squalene derivatives and their use as inhibito will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1697983