Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1976-08-24
1978-02-07
Douglas, Winston A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
260404, 260408, 2604109R, 2604109N, 260413, 260514R, 26014J, 260514K, 260514L, 424308, 424311, 424317, 560 8, 560 76, 560121, 560129, 560190, 560231, A01N 924, C09F 500
Patent
active
040727556
ABSTRACT:
Novel cyclopentanoic acid derivatives of the formula ##STR1## wherein R is selected from the group consisting of ##STR2## and --CH.sub.2 OH, R' is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and a non toxic, pharmaceutically acceptable cation and R.sub.1 is selected from the group consisting of hydrogen, 2-tetrahydropyranyl, branched or straight chain, saturated or unsaturated alkyl of 1 to 4 carbon atoms and ##STR3## and R.sub.2 is selected from the group consisting of straight or branched chain alkyl of 1 to 12 carbon atoms and phenyl with the alkyl and phenyl being optionally substituted with --COOA wherein A is selected from the group consisting of hydrogen, alkali metal, ammonium ion, ion of an organic amine, alkyl and haloalkyl of 1 to 7 alkyl carbon atoms with the proviso that R.sub.1 is not hydrogen or 2-tetrahydropyranyl when R is a carboxylic group, and the OH and R groups on the ring and OR.sub.1 group on the chain may be in either of the two possible positions about the carbon atom to which they are attached having analgesic, anti-inflammatory and smooth muscle relaxant activity.
REFERENCES:
patent: 3880906 (1975-04-01), Spraggins
patent: 3974200 (1976-08-01), Schneider
patent: 3993674 (1976-11-01), Schaub et al.
Chemical Abstracts vol. 72: 72104d (1972).
Buendia Jean
Schalbar Jeanine
Vivat Michel
Douglas Winston A.
Niebling John F.
Roussel Uclaf
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